Assisted Hatching

Assisted hatching is a new method used in IVF procedures. It helps the embryo hatch out from its protective layering before implanting into the woman’s uterus. While developing, the embryo is contained in layers of proteins called the zona pellicuda, which protects the embryo until it reaches the developmental stage of blastocyst. Before successfully implanting the embryo into the uterine lining, it should be hatched out from the zona pellicuda and then attached to the uterus’ walls.

In some cases, embryos are finding difficulties in hatching out from its protective layer. This may happen if the zona pellicuda is so thick or if the embryo does not have sufficient energy to break out from the layer. The method of assisted hatching comes in to solve this problem. It is performed by creating a tiny hole on the outer lining of the protective layer so the embryo can easily come out.

The method of assisted hatching is very delicate and should require massive skill. It is performed under a microscope during the fourth day development of the embryo by using micromanipulation technique. Before this process, the embryo is placed on a petrie dish that contains culture solution. In order to hold the embryo in place, a special pipette is used. A hollow needle containing an acidic solution is used by an embryologist to place it next to the zona pellicuda. From this needle, a small bit of acidic solution is released so it comes in contact with the zona pellicuda. The acidic solution begins to digest the protective layering slowly and create a small hole. Afterwards, the embryo is washed on a special solution before placing it on an incubator. The incubator will safe keep the embryo until embryo transfer can occur.

Assisted hatching was introduced during the 1990s and it can help improve the chances of IVF success in many couples. This method is highly recommended by experts for couples who are having poor results of IVF procedure. However, this method is not suitable for every couple. The only recommended are those women above 37 of age, with elevated FSH on day 3 of menstrual cycle, couples who had experienced failed cycles of IVF, and couples who have embryos of thick zona pellicuda.

Apparently, there are also risks associated with the method of assisted hatching. In particular is the increase of having identical twins since micromanipulation technique is being used by the method. The technique breaks through the zona pellicuda and may cause the embryo to split into two identical portions. Other risks associated include damage to the embryo that may lead to potential death, fetal complications, physical deformity, and conjoined twins. On the part of the mother, the common risks would be mood swings, nausea, infection, and high blood pressure. In most cases these risks are often results of the antibiotics and steroids taken during the procedure of embryo transfer.

Through assisted hatching, the protective layer that surrounds the embryo is compromised, thus it is essential for mothers to take medications that will slow down their immune system as well as prevent infection on the embryo.